Director, Financial Reporting & Technical Accounting

THE OPPORTUNITY insitro is a physical AI company dedicated to unlocking causal human biology and accelerating the delivery of better medicines to patients. Our unique Virtual Human™ platform identifies novel, high-impact genetic intervention points, which our TherML™ platform translates into therapeutics, whether small molecules, biologics, or oligos. With multiple programs in metabolic disease and neuroscience advancing toward the clinic, we are at a pivotal inflection point. insitro is looking for an Director, Financial Reporting & Technical Accounting , with level set by experience, to be the company’s technical accounting expert and the owner of its financial reporting. In this senior individual contributor role, you will lead the year-end audit and financial statements, account for insitro’s most complex transactions, including pharma collaboration revenue, equity financings, and stock-based compensation modifications, and own the 409A valuation, international compliance, and accounting policy. This is also a chance to help build the function: as insitro grows, you will take on ownership of SOX and SEC reporting and help expand the team, playing a central role in building a public-company-ready finance organization, with a clear path to grow in level and scope as the function expands. You will be joining a department that brings together Accounting Operations, FP&A, and Procurement. That structure gives this role visibility into each transaction from the contract and purchase order through to the financial statements. You will partner closely with Strategic Finance on forecasts and on Executive Leadership Team and Board materials. Corporate Development and Legal will also bring you in early on partnerships, financings, and equity matters, so the accounting implications are understood before terms are finalized. Our team is lean, collaborative, and hands-on, with a builder’s mindset. We are high-performing and considered a trusted partner across the company. We are also rebuilding our workflows with Claude and other AI tools, and you will help shape how reporting and technical accounting get done. This position is based at our South San Francisco headquarters, reports to the SVP, Accounting & Financial Operations , and works onsite three days per week as part of our in-person hybrid model. RESPONSIBILITIES Financial Reporting Own the Financial Statements: Direct the annual audit and financial statement process, preparing US GAAP financial statements and footnote disclosures that are accurate, timely, and fully supported Run the Audit: Serve as the primary point of contact for our external auditors, leading audit planning, the PBC list, tie-outs, disclosure checklists, and resolution of audit comments Lead the Disclosure Committee: Own and lead the Disclosure Committee, including setting the agenda, running the meetings, gathering and assessing potential disclosure items from across the company, and documenting conclusions Prepare Executive and Board Materials: Prepare and update financial reporting and accounting content for Executive Leadership Team and Board of Directors materials and support the monthly reporting package and ad hoc investor requests Technical Accounting & Policy Lead Technical Accounting: Lead research and author memos on complex and non-routine transactions, including ASC 606 / ASC 808 collaboration and partnership revenue, ASC 842 leases, and equity and financing instruments Account for the Pipeline: Evaluate the accounting and disclosures for preclinical and clinical activities as our programs advance toward the clinic, including R&D and clinical trial accrual methodologies for CRO and CDMO arrangements Shape Deals Early: Partner with Corporate Development, Legal, and Strategic Finance on partnership agreements, financings, and other transactions so accounting implications are assessed before terms are finalized Leverage Advisors: Serve as the primary liaison to our third-party tax advisor, communicating the tax implications of deals, financial results, and other transactions, and overseeing the tax provision, tax returns, R&D credit study, Section 382 analysis, and equity tax considerations for grants outside the US Set the Policy: Develop, document, and maintain US GAAP accounting policies; monitor FASB developments and lead the adoption of new standards Equity, Valuation, Insurance & International Compliance Own Stock-Based Compensation Accounting: Own ASC 718 accounting and reporting, including expense recognition, award modifications, forfeitures, roll-forwards, and related disclosures, partnering with Legal, which administers grants and the equity plans Support the 409A Valuation: Partner with our third-party valuation advisor on the 409A valuation process, including providing inputs, reviewing key assumptions and conclusions, and supporting audit review Ensure International Compliance: Oversee statutory reporting, audits, and local compliance for our international subsidiary, partnering with local advisors so filing, tax, and regulatory requirements are met on time, and coordinate intercompany agreements and transfer pricing with our tax advisor Support Insurance Renewals: Support the annual insurance renewal process with our insurance brokers, assessing the company’s risk profile and making sure coverage remains adequate as insitro grows and its programs move into the clinic Support the Close: Prepare or review stock-based compensation, contract revenue, and other higher-risk journal entries and reconciliations Controls, Scale & AI Build for Scale: Design and maintain process documentation and internal controls that will scale with the company; when applicable, lead the SOX program, including planning, risk assessment, ITGCs, entity-level controls, remediation, and third-party testing Build and Deploy AI Tools: Put Claude and other AI tools to work across reporting and technical accounting, such as roll-fo